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Cracking the Cytotoxicity Code: Apoptotic Induction of 10-Acetylirciformonin B is Mediated through ROS Generation and Mitochondrial Dysfunction

A marine furanoterpenoid derivative, 10-acetylirciformonin B (10AB), was found to inhibit the proliferation of leukemia, hepatoma, and colon cancer cell lines, with selective and significant potency against leukemia cells. It induced DNA damage and apoptosis in leukemia HL 60 cells. To fully underst...

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Main Authors: Shih, Huei-Chuan, El-Shazly, Mohamed, Juan, Yung-Shun, Chang, Chao-Yuan, Su, Jui-Hsin, Chen, Yu-Cheng, Shih, Shou-Ping, Chen, Huei-Mei, Wu, Yang-Chang, Lu, Mei-Chin
格式: Artigo
語言:Inglês
出版: MDPI 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4052332/
https://ncbi.nlm.nih.gov/pubmed/24857964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md12053072
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