Cracking the Cytotoxicity Code: Apoptotic Induction of 10-Acetylirciformonin B is Mediated through ROS Generation and Mitochondrial Dysfunction

A marine furanoterpenoid derivative, 10-acetylirciformonin B (10AB), was found to inhibit the proliferation of leukemia, hepatoma, and colon cancer cell lines, with selective and significant potency against leukemia cells. It induced DNA damage and apoptosis in leukemia HL 60 cells. To fully underst...

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Autores principales: Shih, Huei-Chuan, El-Shazly, Mohamed, Juan, Yung-Shun, Chang, Chao-Yuan, Su, Jui-Hsin, Chen, Yu-Cheng, Shih, Shou-Ping, Chen, Huei-Mei, Wu, Yang-Chang, Lu, Mei-Chin
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4052332/
https://ncbi.nlm.nih.gov/pubmed/24857964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md12053072
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