The Soluble Heparin-Binding EGF-Like Growth Factor Stimulates EGF Receptor Trafficking to the Nucleus

Most ligands of epidermal growth factor receptor (EGFR) have the ability to induce EGFR translocation into the nucleus, where EGFR acts as an important transcriptional regulator. Soluble form of heparin-binding EGF-like growth factor (sHB-EGF) is one of the ligands for EGFR in many cell types; howev...

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Veröffentlicht in:PLoS One
Hauptverfasser: Korotkevych, Nataliia V., Labyntsev, Andrii Ju., Kolybo, Denis V., Komisarenko, Serhiy V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4446362/
https://ncbi.nlm.nih.gov/pubmed/26016774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0127887
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