Myelotoxicity after high-dose methotrexate in childhood acute leukemia is influenced by 6-mercaptopurine dosing but not by intermediate thiopurine methyltransferase activity

PURPOSE: Through enhancement of 6-mercaptopurine (6MP) bioavailability and inhibition of purine de novo synthesis high-dose methotrexate (HD-MTX) may increase incorporation into DNA of 6-thioguanine nucleotides (6TGN), the cytotoxic metabolites of 6MP. Patients with intermediate activity of thiopuri...

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Publicat a:Cancer Chemother Pharmacol
Autors principals: Levinsen, Mette, Rosthøj, Susanne, Nygaard, Ulrikka, Heldrup, Jesper, Harila-Saari, Arja, Jonsson, Olafur G., Bechensteen, Anne Grete, Abrahamsson, Jonas, Lausen, Birgitte, Frandsen, Thomas L., Weinshilboum, Richard M., Schmiegelow, Kjeld
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4446052/
https://ncbi.nlm.nih.gov/pubmed/25347948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-014-2613-7
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