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Engineering the Substrate Specificity of ADP-Ribosyltransferases for Identifying Direct Protein Targets

Adenosine diphosphate ribosyltransferases (ARTDs; ARTD1–17 in humans) are emerging as critical regulators of cell function in both normal physiology and disease. These enzymes transfer the ADP-ribose moiety from its substrate, nicotinamide adenine dinucleotide (NAD(+)), to amino acids of target prot...

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Publicado en:J Am Chem Soc
Autores principales: Carter-O'Connell, Ian, Jin, Haihong, Morgan, Rory K., David, Larry L., Cohen, Michael S.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4445677/
https://ncbi.nlm.nih.gov/pubmed/24641686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja412897a
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