Multiplexing Seven miRNA-Based shRNAs to Suppress HIV Replication

Multiplexed miRNA-based shRNAs (shRNA-miRs) could have wide potential to simultaneously suppress multiple genes. Here, we describe a simple strategy to express a large number of shRNA-miRs using minimal flanking sequences from multiple endogenous miRNAs. We found that a sequence of 30 nucleotides fl...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Choi, Jang-Gi, Bharaj, Preeti, Abraham, Sojan, Ma, Hongming, Yi, Guohua, Ye, Chunting, Dang, Ying, Manjunath, N, Wu, Haoquan, Shankar, Premlata
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4445613/
https://ncbi.nlm.nih.gov/pubmed/25358251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.205
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