Multiplexing Seven miRNA-Based shRNAs to Suppress HIV Replication

Multiplexed miRNA-based shRNAs (shRNA-miRs) could have wide potential to simultaneously suppress multiple genes. Here, we describe a simple strategy to express a large number of shRNA-miRs using minimal flanking sequences from multiple endogenous miRNAs. We found that a sequence of 30 nucleotides fl...

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Detaylı Bibliyografya
Yayımlandı:Mol Ther
Asıl Yazarlar: Choi, Jang-Gi, Bharaj, Preeti, Abraham, Sojan, Ma, Hongming, Yi, Guohua, Ye, Chunting, Dang, Ying, Manjunath, N, Wu, Haoquan, Shankar, Premlata
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2015
Konular:
Original Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4445613/
https://ncbi.nlm.nih.gov/pubmed/25358251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.205
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