CCR5 Gene Editing of Resting CD4(+) T Cells by Transient ZFN Expression From HIV Envelope Pseudotyped Nonintegrating Lentivirus Confers HIV-1 Resistance in Humanized Mice

CCR5 disruption by zinc finger nucleases (ZFNs) is a promising method for HIV-1 gene therapy. However, successful clinical translation of this strategy necessitates the development of a safe and effective method for delivery into relevant cells. We used non-integrating lentivirus (NILV) for transien...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Mol Ther Nucleic Acids
Main Authors: Yi, Guohua, Choi, Jang Gi, Bharaj, Preeti, Abraham, Sojan, Dang, Ying, Kafri, Tal, Alozie, Ogechika, Manjunath, Manjunath N, Shankar, Premlata
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4222653/
https://ncbi.nlm.nih.gov/pubmed/25268698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2014.52
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados