CCR5 Gene Editing of Resting CD4(+) T Cells by Transient ZFN Expression From HIV Envelope Pseudotyped Nonintegrating Lentivirus Confers HIV-1 Resistance in Humanized Mice

CCR5 disruption by zinc finger nucleases (ZFNs) is a promising method for HIV-1 gene therapy. However, successful clinical translation of this strategy necessitates the development of a safe and effective method for delivery into relevant cells. We used non-integrating lentivirus (NILV) for transien...

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Dettagli Bibliografici
Pubblicato in:Mol Ther Nucleic Acids
Autori principali: Yi, Guohua, Choi, Jang Gi, Bharaj, Preeti, Abraham, Sojan, Dang, Ying, Kafri, Tal, Alozie, Ogechika, Manjunath, Manjunath N, Shankar, Premlata
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2014
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4222653/
https://ncbi.nlm.nih.gov/pubmed/25268698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2014.52
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