AAV2 Delivery of Flt23k Intraceptors Inhibits Murine Choroidal Neovascularization

Long-term inhibition of extracellular vascular endothelial growth factor (VEGF) in the treatment of age-related macular degeneration (AMD) may induce retinal neuronal toxicity and risk other side effects. We developed a novel strategy which inhibits retinal pigment epithelium (RPE)-derived VEGF, spa...

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Detalles Bibliográficos
Publicado en:Mol Ther
Main Authors: Zhang, Xiaohui, Das, Subrata K, Passi, Samuel F, Uehara, Hironori, Bohner, Austin, Chen, Marcus, Tiem, Michelle, Archer, Bonnie, Ambati, Balamurali K
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2015
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4445610/
https://ncbi.nlm.nih.gov/pubmed/25306972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.199
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