Flt23k Nanoparticles Offer Additive Benefit in Graft Survival and Anti-Angiogenic Effects When Combined with Triamcinolone

PURPOSE. To determine if nanoparticles delivering plasmids expressing Flt23k (an anti-VEGF intraceptor) can enhance murine cornea transplant survival and whether their effect is synergistic with steroid therapy. METHODS. Biodegradable PLGA Flt23k loaded or blank nanoparticles were prepared using the...

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Autori principali: Cho, Yang Kyung, Uehara, Hironori, Young, Jason R., Tyagi, Puneet, Kompella, Uday B., Zhang, Xiaohui, Luo, Ling, Singh, Nirbhai, Archer, Bonnie, Ambati, Balamurali K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Association for Research in Vision and Ophthalmology 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3995562/
https://ncbi.nlm.nih.gov/pubmed/22427553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.11-8393
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