Targeted Intraceptor Nanoparticle for Neovascular Macular Degeneration: Preclinical Dose Optimization and Toxicology Assessment

Neovascular age-related macular degeneration (AMD) is treated with anti-VEGF intravitreal injections, which can cause geographic atrophy, infection, and retinal fibrosis. To minimize these toxicities, we developed a nanoparticle delivery system for recombinant Flt23k intraceptor plasmid (RGD.Flt23k....

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Zhang, Xiaohui, Bohner, Austin, Bhuvanagiri, Sai, Uehara, Hironori, Upadhyay, Arun Kumar, Emerson, Lyska L., Bondalapati, Sailaja, Muddana, Santosh Kumar, Fang, Daniel, Li, Miaoling, Sandhu, Zoya, Hussain, Alya, Carroll, Lara S., Tiem, Michelle, Archer, Bonnie, Kompella, Uday, Patil, Rajkumar, Ambati, Balamurali K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2017
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5498805/
https://ncbi.nlm.nih.gov/pubmed/28236576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2017.01.014
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