Small molecule inhibition of group I p21-activated kinases in breast cancer induces apoptosis and potentiates the activity of microtubule stabilizing agents

INTRODUCTION: Breast cancer, the most common cause of cancer-related deaths worldwide among women, is a molecularly and clinically heterogeneous disease. Extensive genetic and epigenetic profiling of breast tumors has recently revealed novel putative driver genes, including p21-activated kinase (PAK...

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Publicado no:Breast Cancer Res
Main Authors: Ong, Christy C, Gierke, Sarah, Pitt, Cameron, Sagolla, Meredith, Cheng, Christine K, Zhou, Wei, Jubb, Adrian M, Strickland, Laura, Schmidt, Maike, Duron, Sergio G, Campbell, David A, Zheng, Wei, Dehdashti, Seameen, Shen, Min, Yang, Nora, Behnke, Mark L, Huang, Wenwei, McKew, John C, Chernoff, Jonathan, Forrest, William F, Haverty, Peter M, Chin, Suet-Feung, Rakha, Emad A, Green, Andrew R, Ellis, Ian O, Caldas, Carlos, O’Brien, Thomas, Friedman, Lori S, Koeppen, Hartmut, Rudolph, Joachim, Hoeflich, Klaus P
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4445529/
https://ncbi.nlm.nih.gov/pubmed/25902869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-015-0564-5
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