Insights into the slow-onset tight-binding inhibition of Escherichia coli Dihydrofolate Reductase: detailed mechanistic characterization of Pyrrolo [3,2-f] quinazoline-1,3-diamine and its derivatives as novel tight-binding inhibitors

Eitemau Tebyg

• Ligand binding studies, preliminary structure-activity relationship and detailed mechanistic characterization of 1-phenyl-6,6-dimethyl-1,3,5-triazine-2,4-diamine derivatives as inhibitors of Escherichia coli dihydrofolate reductase
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  Cyhoeddwyd: (2015)
• Antimalarial Activities of New Pyrrolo[3,2-f]Quinazoline-1,3-Diamine Derivatives
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  Cyhoeddwyd: (2005)
• Discovery of a Potent Anti-tumor Agent through Regioselective Mono-N-acylation of 7H-Pyrrolo[3,2-f]quinazoline-1,3-diamine
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  Cyhoeddwyd: (2013)
• The kinetics of slow-binding and slow, tight-binding inhibition: the effects of substrate depletion.
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  Cyhoeddwyd: (1993)
• Antiproliferative activities of halogenated pyrrolo[3,2-d]pyrimidines
  gan: Temburnikar, Kartik W., et al.
  Cyhoeddwyd: (2015)