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Photoactivation of hypericin decreases the viability of RINm5F insulinoma cells through reduction in JNK/ERK phosphorylation and elevation of caspase-9/caspase-3 cleavage and Bax-to-Bcl-2 ratio

Insulinomas cause neuroglycopenic symptoms, permanent neurological damage and even death. Current available therapies cannot satisfactorily treat malignant insulinomas and some benign insulinomas. The promising phototherapeutic results and harmless side effects of hypericin in some cancer treatments...

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Detalhes bibliográficos
Publicado no:Biosci Rep
Main Authors: Yi, Jingwen, Yang, Xiaoguang, Zheng, Lihua, Yang, Guang, Sun, Luguo, Bao, Yongli, Wu, Yin, Huang, Yanxin, Yu, Chunlei, Yang, Shao-Nian, Li, Yuxin
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4445353/
https://ncbi.nlm.nih.gov/pubmed/26182357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20150028
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