Trovafloxacin-induced Replication Stress Sensitizes HepG2 Cells to Tumor Necrosis Factor-alpha-induced Cytotoxicity Mediated by Extracellular Signal-regulated Kinase and Ataxia Telangiectasia and Rad3-related

Use of the fluoroquinolone antibiotic trovafloxacin (TVX) was restricted due to idiosyncratic, drug-induced liver injury (IDILI). Previous studies demonstrated that tumor necrosis factor-alpha (TNF) and TVX interact to cause death of hepatocytes in vitro that was associated with prolonged activation...

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Detalhes bibliográficos
Publicado no:Toxicology
Main Authors: Beggs, Kevin M., Maiuri, Ashley R., Fullerton, Aaron M., Poulsen, Kyle L., Breier, Anna B., Ganey, Patricia E., Roth, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4445241/
https://ncbi.nlm.nih.gov/pubmed/25748550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tox.2015.03.002
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