Trovafloxacin Enhances Lipopolysaccharide-Stimulated Production of Tumor Necrosis Factor-α by Macrophages: Role of the DNA Damage Response

Trovafloxacin (TVX) is a drug that has caused idiosyncratic, drug-induced liver injury (IDILI) in humans. In a murine model of IDILI, otherwise nontoxic doses of TVX and the inflammagen lipopolysaccharide (LPS) interacted to produce pronounced hepatocellular injury. The liver injury depended on a TV...

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Bibliografiset tiedot
Päätekijät: Poulsen, Kyle L., Olivero-Verbel, Jesus, Beggs, Kevin M., Ganey, Patricia E., Roth, Robert A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The American Society for Pharmacology and Experimental Therapeutics 2014
Aiheet:
Toxicology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4056269/
https://ncbi.nlm.nih.gov/pubmed/24817034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.114.214189
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