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Design, Synthesis and Evaluation of Marinopyrrole Derivatives as Selective Inhibitors of Mcl-1 Binding to Pro-apoptotic Bim and Dual Mcl-1/Bcl-xL Inhibitors

Inhibition of anti-apoptotic Mcl-1 is a promising anticancer strategy to overcome the survival and chemoresistance of a broad spectrum of human cancers. We previously reported on the identification of a natural product marinopyrrole A (1) that induces apoptosis in Mcl-1-dependent cells through Mcl-1...

詳細記述

保存先:
書誌詳細
出版年:Eur J Med Chem
主要な著者: Li, Rongshi, Cheng, Chunwei, Balasis, Maria E., Liu, Yan, Garner, Thomas P., Daniel, Kenyon G., Li, Jerry, Qin, Yong, Gavathiotis, Evripidis, Sebti, Said M.
フォーマット: Artigo
言語:Inglês
出版事項: 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4445146/
https://ncbi.nlm.nih.gov/pubmed/25437618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2014.11.035
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