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T-type calcium channel antagonists, mibefradil and NNC-55-0396 inhibit cell proliferation and induce cell apoptosis in leukemia cell lines

BACKGROUND: T-type Ca(2+) channels are often aberrantly expressed in different human cancers and participate in the regulation of cell cycle progression, proliferation and death. Methods: RT-PCR, Q-PCR, western blotting and whole-cell patch-clamp recording were employed to assess the expression of T...

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Bibliografiske detaljer
Udgivet i:J Exp Clin Cancer Res
Main Authors: Huang, Weifeng, Lu, Chunjing, Wu, Yong, Ouyang, Shou, Chen, Yuanzhong
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4443536/
https://ncbi.nlm.nih.gov/pubmed/25989794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-015-0171-4
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