Analysis of the contribution of an amphiphilic alpha-helix to the structure and to the function of ricin A chain.
The A chain of ricin is a cytotoxic RNA N-glycosidase that inactivates eukaryotic ribosomes. The contribution of the amphiphilic helix D, which is distant from the active site, to the catalysis of the depurination of the adenosine at position 4324 in 28S rRNA has been examined by systematic deletion...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1994
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC44435/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8052614/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.16.7530 |
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