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Obstruction of adaptation in diploids by recessive, strongly deleterious alleles

Recessive deleterious mutations are common, causing many genetic disorders in humans and producing inbreeding depression in the majority of sexually reproducing diploids. The abundance of recessive deleterious mutations in natural populations suggests they are likely to be present on a chromosome wh...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Assaf, Zoe June, Petrov, Dmitri A., Blundell, Jamie R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4443376/
https://ncbi.nlm.nih.gov/pubmed/25941393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1424949112
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