Analysis of Repair Mechanisms following an Induced Double-Strand Break Uncovers Recessive Deleterious Alleles in the Candida albicans Diploid Genome

The diploid genome of the yeast Candida albicans is highly plastic, exhibiting frequent loss-of-heterozygosity (LOH) events. To provide a deeper understanding of the mechanisms leading to LOH, we investigated the repair of a unique DNA double-strand break (DSB) in the laboratory C. albicans SC5314 s...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: Feri, Adeline, Loll-Krippleber, Raphaël, Commere, Pierre-Henri, Maufrais, Corinne, Sertour, Natacha, Schwartz, Katja, Sherlock, Gavin, Bougnoux, Marie-Elisabeth, d’Enfert, Christophe, Legrand, Mélanie
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5061868/
https://ncbi.nlm.nih.gov/pubmed/27729506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01109-16
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