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ULK1 targets Beclin-1 in autophagy

The substrates of mammalian ULK1/2 and its yeast homologue Atg1 in autophagy have remained elusive. The class III phosphatidylinositol 3-kinase component Beclin-1 has now been identified as a physiological substrate of the ULK kinases in autophagy following amino acid starvation, therefore suggestin...

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Detalles Bibliográficos
Publicado en:Nat Cell Biol
Main Authors: Nazarko, Volodymyr Y., Zhong, Qing
Formato: Artigo
Idioma:Inglês
Publicado: 2013
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4442023/
https://ncbi.nlm.nih.gov/pubmed/23817237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2797
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