Metabolic and molecular responses to leucine enriched branched chain amino acid supplementation in the skeletal muscle of alcoholic cirrhosis

BACKGROUND: Skeletal muscle loss (sarcopenia) is a major clinical complication in alcoholic cirrhosis with no effective therapy. Skeletal muscle autophagic proteolysis and myostatin expression (inhibitor of protein synthesis) are increased in cirrhosis and believed to contribute to anabolic resistan...

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Gepubliceerd in:Hepatology
Hoofdauteurs: Tsien, Cynthia, Davuluri, Gangarao, Singh, Dharmvir, Allawy, Allawy, Ten Have, Gabriella AM, Thapaliya, Samjhana, Schulze, John M, Barnes, David, McCullough, Arthur J, Engelen, Marielle P.K.J., Deutz, Nicolaas E.P., Dasarathy, Srinivasan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4441611/
https://ncbi.nlm.nih.gov/pubmed/25613922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.27717
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