Rescue of DNA-PK Signaling and T-Cell Differentiation by Targeted Genome Editing in a prkdc Deficient iPSC Disease Model

In vitro disease modeling based on induced pluripotent stem cells (iPSCs) provides a powerful system to study cellular pathophysiology, especially in combination with targeted genome editing and protocols to differentiate iPSCs into affected cell types. In this study, we established zinc-finger nucl...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Rahman, Shamim H., Kuehle, Johannes, Reimann, Christian, Mlambo, Tafadzwa, Alzubi, Jamal, Maeder, Morgan L., Riedel, Heimo, Fisch, Paul, Cantz, Tobias, Rudolph, Cornelia, Mussolino, Claudio, Joung, J. Keith, Schambach, Axel, Cathomen, Toni
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4441453/
https://ncbi.nlm.nih.gov/pubmed/26000857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005239
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