Rescue of DNA-PK Signaling and T-Cell Differentiation by Targeted Genome Editing in a prkdc Deficient iPSC Disease Model

In vitro disease modeling based on induced pluripotent stem cells (iPSCs) provides a powerful system to study cellular pathophysiology, especially in combination with targeted genome editing and protocols to differentiate iPSCs into affected cell types. In this study, we established zinc-finger nucl...

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Bibliografiska uppgifter
I publikationen:PLoS Genet
Huvudupphovsmän: Rahman, Shamim H., Kuehle, Johannes, Reimann, Christian, Mlambo, Tafadzwa, Alzubi, Jamal, Maeder, Morgan L., Riedel, Heimo, Fisch, Paul, Cantz, Tobias, Rudolph, Cornelia, Mussolino, Claudio, Joung, J. Keith, Schambach, Axel, Cathomen, Toni
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2015
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4441453/
https://ncbi.nlm.nih.gov/pubmed/26000857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005239
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