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INSULIN BLOCKS CYTOCHROME C RELEASE IN THE REPERFUSED BRAIN THROUGH PI3-K SIGNALING AND BY PROMOTING BAX/BCL-X(L)BINDING
The critical event of the intrinsic pathway of apoptosis following transient global brain ischemia is the release of cytochrome c from the mitochondria. In vitro studies have shown that insulin can signal specifically via PI3K and Akt to prevent cytochrome c release. Therefore, insulin may exert its...
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| Publicado no: | J Neurochem |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4441329/ https://ncbi.nlm.nih.gov/pubmed/18518905 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2008.05473.x |
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