piRNA-directed cleavage of meiotic transcripts regulates spermatogenesis

MIWI catalytic activity is required for spermatogenesis, indicating that piRNA-guided cleavage is critical for germ cell development. To identify meiotic piRNA targets, we augmented the mouse piRNA repertoire by introducing a human meiotic piRNA cluster. This triggered a spermatogenesis defect by in...

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Detalles Bibliográficos
Publicado en:Genes Dev
Autores principales: Goh, Wee Siong Sho, Falciatori, Ilaria, Tam, Oliver H., Burgess, Ralph, Meikar, Oliver, Kotaja, Noora, Hammell, Molly, Hannon, Gregory J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4441051/
https://ncbi.nlm.nih.gov/pubmed/25995188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.260455.115
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