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piRNA-directed cleavage of meiotic transcripts regulates spermatogenesis
MIWI catalytic activity is required for spermatogenesis, indicating that piRNA-guided cleavage is critical for germ cell development. To identify meiotic piRNA targets, we augmented the mouse piRNA repertoire by introducing a human meiotic piRNA cluster. This triggered a spermatogenesis defect by in...
Tallennettuna:
| Julkaisussa: | Genes Dev |
|---|---|
| Päätekijät: | , , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Cold Spring Harbor Laboratory Press
2015
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4441051/ https://ncbi.nlm.nih.gov/pubmed/25995188 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.260455.115 |
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