A genome-wide RNAi screen identifies factors required for distinct stages of C. elegans piRNA biogenesis

In animals, piRNAs and their associated Piwi proteins guard germ cell genomes against mobile genetic elements via an RNAi-like mechanism. In Caenorhabditis elegans, 21U-RNAs comprise the piRNA class, and these collaborate with 22G RNAs via unclear mechanisms to discriminate self from nonself and sel...

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Kaydedildi:
Detaylı Bibliyografya
Asıl Yazarlar: Goh, Wee-Siong Sho, Seah, Jun Wen Eugene, Harrison, Emily J., Chen, Caifu, Hammell, Christopher M., Hannon, Gregory J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Cold Spring Harbor Laboratory Press 2014
Konular:
Resource/Methodology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4015493/
https://ncbi.nlm.nih.gov/pubmed/24696458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.235622.113
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