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A genome-wide RNAi screen identifies factors required for distinct stages of C. elegans piRNA biogenesis
In animals, piRNAs and their associated Piwi proteins guard germ cell genomes against mobile genetic elements via an RNAi-like mechanism. In Caenorhabditis elegans, 21U-RNAs comprise the piRNA class, and these collaborate with 22G RNAs via unclear mechanisms to discriminate self from nonself and sel...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4015493/ https://ncbi.nlm.nih.gov/pubmed/24696458 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.235622.113 |
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