Mucosal delivery of a vectored RSV vaccine is safe and elicits protective immunity in rodents and nonhuman primates

Respiratory Syncytial Virus (RSV) is a leading cause of severe respiratory disease in infants and the elderly. No vaccine is presently available to address this major unmet medical need. We generated a new genetic vaccine based on chimpanzee Adenovirus (PanAd3-RSV) and Modified Vaccinia Ankara RSV (...

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Publicado en:Mol Ther Methods Clin Dev
Autores principales: Pierantoni, Angiolo, Esposito, Maria Luisa, Ammendola, Virginia, Napolitano, Federico, Grazioli, Fabiana, Abbate, Adele, del Sorbo, Mariarosaria, Siani, Loredana, D’Alise, Anna Morena, Taglioni, Alessandra, Perretta, Gemma, Siccardi, Antonio, Soprana, Elisa, Panigada, Maddalena, Thom, Michelle, Scarselli, Elisa, Folgori, Antonella, Colloca, Stefano, Taylor, Geraldine, Cortese, Riccardo, Nicosia, Alfredo, Capone, Stefania, Vitelli, Alessandra
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4441047/
https://ncbi.nlm.nih.gov/pubmed/26015988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtm.2015.18
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