Design and Structural Requirements of the Potent and Safe TLR-9 Agonistic Immunomodulator MGN1703

Single-stranded oligodeoxynucleotides (ODN), containing nonmethylated cytosine–guanine motifs (CpG ODN), are recognized by the innate immune system as “danger signals.” CpG ODN are efficacious immunomodulators but require phosphorothioate (PT) or other backbone modifications for metabolic stability,...

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Detaylı Bibliyografya
Yayımlandı:Nucleic Acid Ther
Asıl Yazarlar: Schmidt, Manuel, Hagner, Nicole, Marco, Alberto, König-Merediz, Sven A., Schroff, Matthias, Wittig, Burghardt
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Mary Ann Liebert, Inc. 2015
Konular:
Original Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4440985/
https://ncbi.nlm.nih.gov/pubmed/25826686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/nat.2015.0533
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