Design and Structural Requirements of the Potent and Safe TLR-9 Agonistic Immunomodulator MGN1703

Single-stranded oligodeoxynucleotides (ODN), containing nonmethylated cytosine–guanine motifs (CpG ODN), are recognized by the innate immune system as “danger signals.” CpG ODN are efficacious immunomodulators but require phosphorothioate (PT) or other backbone modifications for metabolic stability,...

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Detalhes bibliográficos
Publicado no:Nucleic Acid Ther
Main Authors: Schmidt, Manuel, Hagner, Nicole, Marco, Alberto, König-Merediz, Sven A., Schroff, Matthias, Wittig, Burghardt
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2015
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4440985/
https://ncbi.nlm.nih.gov/pubmed/25826686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/nat.2015.0533
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