Efficacy of Adjuvant 5-Fluorouracil Therapy for Patients with EMAST-Positive Stage II/III Colorectal Cancer

Elevated Microsatellite Alterations at Selected Tetranucleotide repeats (EMAST) is a genetic signature found in up to 60% of colorectal cancers (CRCs) that is caused by somatic dysfunction of the DNA mismatch repair (MMR) protein hMSH3. We have previously shown in vitro that recognition of 5-fluorou...

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Veröffentlicht in:PLoS One
Hauptverfasser: Hamaya, Yasushi, Guarinos, Carla, Tseng-Rogenski, Stephanie S., Iwaizumi, Moriya, Das, Ritabrata, Jover, Rodrigo, Castells, Antoni, Llor, Xavier, Andreu, Montserrat, Carethers, John M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4440728/
https://ncbi.nlm.nih.gov/pubmed/25996601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0127591
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