Oxidative Stress Induces Nuclear-to-Cytosol Shift of hMSH3, a Potential Mechanism for EMAST in Colorectal Cancer Cells

BACKGROUND: Elevated microsatellite alterations at selected tetranucleotide repeats (EMAST) is a genetic signature observed in 60% of sporadic colorectal cancers (CRCs). Unlike microsatellite unstable CRCs where hypermethylation of the DNA mismatch repair (MMR) gene hMLH1’s promoter is causal, the p...

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Detalhes bibliográficos
Main Authors: Tseng-Rogenski, Stephanie S., Chung, Heekyung, Wilk, Maike B., Zhang, Shuai, Iwaizumi, Moriya, Carethers, John M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3511561/
https://ncbi.nlm.nih.gov/pubmed/23226332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0050616
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