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Reduced oxidative tissue damage during endotoxemia in IRAK-1 deficient mice

The generation of reactive oxygen species (ROS) triggered by bacterial endotoxin lipopolysaccharide (LPS) plays a key role during the pathogenesis of sepsis. Given the key role that the interleukin-1 receptor associated kinase-1 (IRAK-1) plays in LPS-mediated Toll-like-receptor 4 (TLR4) pathway, we...

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Détails bibliographiques
Publié dans:Mol Immunol
Auteurs principaux: Singh, Neeraj, Li, Liwu
Format: Artigo
Langue:Inglês
Publié: 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4440666/
https://ncbi.nlm.nih.gov/pubmed/22364946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2012.01.011
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