Deletion of Mecom in mouse results in early-onset spinal deformity and osteopenia

Recent studies have indicated a role for a MECOM allele in susceptibility to osteoporotic fractures in humans. We have generated a mutation in Mecom in mouse (termed ME(m1)) via lacZ knock-in into the upstream transcription start site for the gene, resulting in disruption of Mds1 and Mds1-Evi1 trans...

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Publicat a:Bone
Autors principals: Juneja, Subhash C., Vonica, Alin, Zeiss, Caroline, Lezon-Geyda, Kimberly, Yatsula, Bogdan, Sell, David R., Monnier, Vincent M., Lin, Sharon, Ardito, Thomas, Eyre, David, Reynolds, David, Yao, Zhenqiang, Awad, Hani A., Yu, Hongbo, Wilson, Michael, Honnons, Sylvie, Boyce, Brendan F., Xing, Lianping, Zhang, Yi, Perkins, Archibald S.
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4440591/
https://ncbi.nlm.nih.gov/pubmed/24316420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2013.11.020
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