Constitutive μ-Opioid Receptor Activity Leads to Long-term Endogenous Analgesia and Dependence

Opioid receptor antagonists increase hyperalgesia in humans and animals, indicating that endogenous activation of opioid receptors provides relief from acute pain; however, the mechanisms of long-term opioid inhibition of pathological pain have remained elusive. We found that tissue injury produced...

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Pubblicato in:Science
Autori principali: Corder, G., Doolen, S., Donahue, R. R., Winter, M.K., Jutras, B.L., He, Y., Hu, X., Wieskopf, J.S., Mogil, J.S., Storm, D.R., Wang, Z.J., McCarson, K.E., Taylor, B.K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4440417/
https://ncbi.nlm.nih.gov/pubmed/24052307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1239403
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