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Constitutive μ-Opioid Receptor Activity Leads to Long-term Endogenous Analgesia and Dependence
Opioid receptor antagonists increase hyperalgesia in humans and animals, indicating that endogenous activation of opioid receptors provides relief from acute pain; however, the mechanisms of long-term opioid inhibition of pathological pain have remained elusive. We found that tissue injury produced...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Science |
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| Κύριοι συγγραφείς: | , , , , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2013
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4440417/ https://ncbi.nlm.nih.gov/pubmed/24052307 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1239403 |
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