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Constitutive μ-Opioid Receptor Activity Leads to Long-term Endogenous Analgesia and Dependence
Opioid receptor antagonists increase hyperalgesia in humans and animals, indicating that endogenous activation of opioid receptors provides relief from acute pain; however, the mechanisms of long-term opioid inhibition of pathological pain have remained elusive. We found that tissue injury produced...
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| 出版年: | Science |
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| 主要な著者: | , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4440417/ https://ncbi.nlm.nih.gov/pubmed/24052307 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1239403 |
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