The Oncogenic MicroRNA miR-21 Promotes Regulated Necrosis in Mice

MicroRNAs (miRNAs) regulate apoptosis, yet their role in regulated necrosis remains unknown. miR-21 is overexpressed in nearly all human cancer types and its role as an oncogene is suggested to largely depend on its anti-apoptotic action. Here we show that miR-21 is overexpressed in a murine model o...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Ma, Xiaodong, Conklin, Daniel J., Li, Fenge, Dai, Zhongping, Hua, Xiang, Li, Yan, Xu-Monette, Zijun Y., Young, Ken H., Xiong, Wei, Wysoczynski, Marcin, Sithu, Srinivas D., Srivastava, Sanjay, Bhatnagar, Aruni, Li, Yong
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4440243/
https://ncbi.nlm.nih.gov/pubmed/25990308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8151
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