Sustained Efficacy and Seroconversion with the Toll-Like Receptor 7 Agonist GS-9620 in the Woodchuck Model of Chronic Hepatitis B

BACKGROUND & AIMS: New therapies for chronic hepatitis B (CHB) are urgently needed since current treatments rarely lead to cure. We evaluated whether the oral small molecule toll-like receptor (TLR7) agonist GS-9620 could induce durable anti-viral efficacy in woodchucks chronically infected with...

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Gepubliceerd in:J Hepatol
Hoofdauteurs: Menne, Stephan, Tumas, Daniel B., Liu, Katherine H., Thampi, Linta, AlDeghaither, Dalal, Baldwin, Betty H., Bellezza, Christine A., Cote, Paul J., Zheng, Jim, Halcomb, Randall, Fosdick, Abigail, Fletcher, Simon P., Daffis, Stephane, Li, Li, Yue, Peng, Wolfgang, Grushenka H. I., Tennant, Bud C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4439359/
https://ncbi.nlm.nih.gov/pubmed/25559326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2014.12.026
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