GS-9620, an Oral Agonist of Toll-Like Receptor-7, Induces Prolonged Suppression of Hepatitis B Virus in Chronically Infected Chimpanzees

BACKGROUND & AIMS: Direct-acting anti-viral agents suppress hepatitis B virus (HBV) load but must be given lifelong. Stimulation of the innate immune system could increase its ability to control the virus and have long lasting effects, after a finite regimen. We investigated the effects of immun...

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Detalhes bibliográficos
Main Authors: Lanford, Robert E., Guerra, Bernadette, Chavez, Deborah, Giavedoni, Luis, Hodara, Vida L., Brasky, Kathleen M., Fosdick, Abigail, Frey, Christian R., Zheng, Jim, Wolfgang, Grushenka, Halcomb, Randall L., Tumas, Daniel B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3691056/
https://ncbi.nlm.nih.gov/pubmed/23415804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2013.02.003
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