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Kinetic Analysis and Quantification of [11C]Martinostat for in vivo HDAC Imaging of the Brain
Epigenetic mechanisms mediated by histone deacetylases (HDACs) have been implicated in a wide-range of CNS disorders and may offer new therapeutic opportunities. In vivo evaluation of HDAC density and drug occupancy has become possible with [(11)C]Martinostat, which exhibits selectivity for a subset...
Tallennettuna:
| Julkaisussa: | ACS Chem Neurosci |
|---|---|
| Päätekijät: | , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2015
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4439341/ https://ncbi.nlm.nih.gov/pubmed/25768025 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.5b00066 |
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