Three Huntington’s Disease Specific Mutation-Carrying Human Embryonic Stem Cell Lines Have Stable Number of CAG Repeats upon In Vitro Differentiation into Cardiomyocytes

Huntington disease (HD; OMIM 143100), a progressive neurodegenerative disorder, is caused by an expanded trinucleotide CAG (polyQ) motif in the HTT gene. Cardiovascular symptoms, often present in early stage HD patients, are, in general, ascribed to dysautonomia. However, cardio-specific expression...

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Udgivet i:PLoS One
Main Authors: Jacquet, Laureen, Neueder, Andreas, Földes, Gabor, Karagiannis, Panagiotis, Hobbs, Carl, Jolinon, Nelly, Mioulane, Maxime, Sakai, Takao, Harding, Sian E., Ilic, Dusko
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4438866/
https://ncbi.nlm.nih.gov/pubmed/25993131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0126860
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