Fibroblast growth factor-2 regulates human cardiac myofibroblast-mediated extracellular matrix remodeling

BACKGROUND: Tissue fibrosis and chamber remodeling is a hallmark of the failing heart and the final common pathway for heart failure of diverse etiologies. Sustained elevation of pro-fibrotic cytokine transforming growth factor-beta1 (TGFβ1) induces cardiac myofibroblast-mediated fibrosis and progre...

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Détails bibliographiques
Publié dans:J Transl Med
Auteurs principaux: Svystonyuk, Daniyil A, Ngu, Janet MC, Mewhort, Holly EM, Lipon, Brodie D, Teng, Guoqi, Guzzardi, David G, Malik, Getanshu, Belke, Darrell D, Fedak, Paul WM
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2015
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4438633/
https://ncbi.nlm.nih.gov/pubmed/25948488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-015-0510-4
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