Fibroblast growth factor-2 regulates human cardiac myofibroblast-mediated extracellular matrix remodeling

BACKGROUND: Tissue fibrosis and chamber remodeling is a hallmark of the failing heart and the final common pathway for heart failure of diverse etiologies. Sustained elevation of pro-fibrotic cytokine transforming growth factor-beta1 (TGFβ1) induces cardiac myofibroblast-mediated fibrosis and progre...

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Detalhes bibliográficos
Publicado no:J Transl Med
Main Authors: Svystonyuk, Daniyil A, Ngu, Janet MC, Mewhort, Holly EM, Lipon, Brodie D, Teng, Guoqi, Guzzardi, David G, Malik, Getanshu, Belke, Darrell D, Fedak, Paul WM
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4438633/
https://ncbi.nlm.nih.gov/pubmed/25948488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-015-0510-4
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