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Primate Phencyclidine Model of Schizophrenia: Sex-Specific Effects on Cognition, Brain Derived Neurotrophic Factor, Spine Synapses, and Dopamine Turnover in Prefrontal Cortex

BACKGROUND: Cognitive deficits are a core symptom of schizophrenia, yet they remain particularly resistant to treatment. The model provided by repeatedly exposing adult nonhuman primates to phencyclidine has generated important insights into the neurobiology of these deficits, but it remains possibl...

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Pubblicato in:Int J Neuropsychopharmacol
Autori principali: Elsworth, John D., Groman, Stephanie M., Jentsch, James D., Leranth, Csaba, Redmond, D. Eugene, Kim, Jung D., Diano, Sabrina, Roth, Robert H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4438537/
https://ncbi.nlm.nih.gov/pubmed/25522392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ijnp/pyu048
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