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Primate Phencyclidine Model of Schizophrenia: Sex-Specific Effects on Cognition, Brain Derived Neurotrophic Factor, Spine Synapses, and Dopamine Turnover in Prefrontal Cortex

BACKGROUND: Cognitive deficits are a core symptom of schizophrenia, yet they remain particularly resistant to treatment. The model provided by repeatedly exposing adult nonhuman primates to phencyclidine has generated important insights into the neurobiology of these deficits, but it remains possibl...

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Bibliografski detalji
Izdano u:Int J Neuropsychopharmacol
Glavni autori: Elsworth, John D., Groman, Stephanie M., Jentsch, James D., Leranth, Csaba, Redmond, D. Eugene, Kim, Jung D., Diano, Sabrina, Roth, Robert H.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4438537/
https://ncbi.nlm.nih.gov/pubmed/25522392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ijnp/pyu048
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