Primate Phencyclidine Model of Schizophrenia: Sex-Specific Effects on Cognition, Brain Derived Neurotrophic Factor, Spine Synapses, and Dopamine Turnover in Prefrontal Cortex

BACKGROUND: Cognitive deficits are a core symptom of schizophrenia, yet they remain particularly resistant to treatment. The model provided by repeatedly exposing adult nonhuman primates to phencyclidine has generated important insights into the neurobiology of these deficits, but it remains possibl...

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Detalhes bibliográficos
Publicado no:Int J Neuropsychopharmacol
Main Authors: Elsworth, John D., Groman, Stephanie M., Jentsch, James D., Leranth, Csaba, Redmond, D. Eugene, Kim, Jung D., Diano, Sabrina, Roth, Robert H.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4438537/
https://ncbi.nlm.nih.gov/pubmed/25522392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ijnp/pyu048
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