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Phencyclidine-induced Loss of Asymmetric Spine Synapses in Rodent Prefrontal Cortex is Reversed by Acute and Chronic Treatment with Olanzapine

Enduring cognitive deficits exist in schizophrenic patients, long-term abusers of phencyclidine (PCP), as well as in animal PCP models of schizophrenia. It has been suggested that cognitive performance and memory processes are coupled with remodeling of pyramidal dendritic spine synapses in prefront...

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Detalhes bibliográficos
Main Authors: Elsworth, John D, Morrow, Bret A, Hajszan, Tibor, Leranth, Csaba, Roth, Robert H
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3158322/
https://ncbi.nlm.nih.gov/pubmed/21677652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2011.96
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