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Trans-splicing Group I Intron Targeting Hepatitis C Virus IRES Mediates Cell Death upon Viral Infection in Huh7.5 Cells
The HCV-IRES sequence is vital for both protein translation and genome replication and serves as a potential target for anti-HCV therapy. We constructed a series of anti-HCV Group I introns (αHCV-GrpIs) to attack conserved target sites within the HCV IRES. These αHCV-GrpIs were designed to mediate a...
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| Publié dans: | Virology |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4437843/ https://ncbi.nlm.nih.gov/pubmed/25840398 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2015.02.023 |
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