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Computational design of protein antigens that interact with the CDR H3 loop of HIV broadly neutralizing antibody 2F5
Rational design of proteins with novel binding specificities and increased affinity is one of the major goals of computational protein design. Epitope-scaffolds are a new class of antigens engineered by transplanting viral epitopes of pre-defined structure to protein scaffolds, or by building protei...
Kaydedildi:
| Yayımlandı: | Proteins |
|---|---|
| Asıl Yazarlar: | , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2014
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4437801/ https://ncbi.nlm.nih.gov/pubmed/25043744 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.24641 |
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