High Glutathione and Glutathione Peroxidase-2 Levels Mediate Cell-Type-Specific DNA Damage Protection in Human Induced Pluripotent Stem Cells

Pluripotent stem cells must strictly maintain genomic integrity to prevent transmission of mutations. In human induced pluripotent stem cells (iPSCs), we found that genome surveillance is achieved via two ways, namely, a hypersensitivity to apoptosis and a very low accumulation of DNA lesions. The l...

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Detaylı Bibliyografya
Yayımlandı:Stem Cell Reports
Asıl Yazarlar: Dannenmann, Benjamin, Lehle, Simon, Hildebrand, Dominic G., Kübler, Ayline, Grondona, Paula, Schmid, Vera, Holzer, Katharina, Fröschl, Mirjam, Essmann, Frank, Rothfuss, Oliver, Schulze-Osthoff, Klaus
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Elsevier 2015
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4437487/
https://ncbi.nlm.nih.gov/pubmed/25937369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2015.04.004
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