High Glutathione and Glutathione Peroxidase-2 Levels Mediate Cell-Type-Specific DNA Damage Protection in Human Induced Pluripotent Stem Cells

Pluripotent stem cells must strictly maintain genomic integrity to prevent transmission of mutations. In human induced pluripotent stem cells (iPSCs), we found that genome surveillance is achieved via two ways, namely, a hypersensitivity to apoptosis and a very low accumulation of DNA lesions. The l...

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Publié dans:Stem Cell Reports
Auteurs principaux: Dannenmann, Benjamin, Lehle, Simon, Hildebrand, Dominic G., Kübler, Ayline, Grondona, Paula, Schmid, Vera, Holzer, Katharina, Fröschl, Mirjam, Essmann, Frank, Rothfuss, Oliver, Schulze-Osthoff, Klaus
Format: Artigo
Langue:Inglês
Publié: Elsevier 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4437487/
https://ncbi.nlm.nih.gov/pubmed/25937369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2015.04.004
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