High Glutathione and Glutathione Peroxidase-2 Levels Mediate Cell-Type-Specific DNA Damage Protection in Human Induced Pluripotent Stem Cells

Pluripotent stem cells must strictly maintain genomic integrity to prevent transmission of mutations. In human induced pluripotent stem cells (iPSCs), we found that genome surveillance is achieved via two ways, namely, a hypersensitivity to apoptosis and a very low accumulation of DNA lesions. The l...

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Publicado no:Stem Cell Reports
Main Authors: Dannenmann, Benjamin, Lehle, Simon, Hildebrand, Dominic G., Kübler, Ayline, Grondona, Paula, Schmid, Vera, Holzer, Katharina, Fröschl, Mirjam, Essmann, Frank, Rothfuss, Oliver, Schulze-Osthoff, Klaus
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4437487/
https://ncbi.nlm.nih.gov/pubmed/25937369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2015.04.004
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